Cisplatin-based combination chemotherapy

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August undefined, 2024

WebAs in the clinic cisplatin is coadministered as a combination with other chemotherapeutic substances, cross-resistance of LTTs towards gemcitabine and doxorubicin was determined. Interestingly, a 16-fold cross-resistance to gemcitabine in RT-112-LTT and a 2.1-fold cross-resistance to doxorubicin in T-24-LTT were observed ( Table S1 ). 2.2. WebSep 18, 2024 · NCBI Bookshelf

Biomarkers for chemotherapy and drug resistance in the …

WebCisplatin-based chemotherapy (CBC) is highly efficacious for advanced cervical cancer; its efficacy can be enhanced by combining with 15 mg/kg (standard dose) bevacizumab (BEV). However, this standard dose is associated with various adverse events (AEs). Web1 day ago · KEYTRUDA, in combination with enfortumab vedotin, is indicated for the treatment of patients with locally advanced or metastatic urothelial carcinoma (mUC) who … chinesische popstars

Combination Chemotherapy: History, Benefits, and Risks

WebFeb 23, 2024 · Cisplatin-based neoadjuvant chemotherapy is the standard of care for patients with muscle-invasive bladder cancer (MIBC). It yields a 30% to 40% pathologic complete response rate and correlates... WebCisplatin Vial. - Uses, Side Effects, and More. Cisplatin may cause severe kidney problems, nerve problems, and severe nausea and vomiting. Nerve problems may occur … Webwith solid tumors receiving cisplatin-based highly emetogenic chemotherapy (HEC). Support Care Cancer. 2015 Oct;23(10):2917–23. ... Kosaka Y, Okita K, Yuki S, et al. One-Day Versus Three-Day Dexamethasone in Combination with Palonosetron for the Prevention of Chemotherapy-Induced Nausea and Vomiting: A Systematic Review and … grange of aberbothrie

Management of Chemotherapy Induced Nausea and Vomiting in …

Cisplatin Cancer information Cancer Research UK

WebPlatinum-based chemotherapy with the substitution of paclitaxel is the most commonly used combination for treating advanced-stage EOC after surgery [17,18]. Unfortunately, cancer cells either intrinsically are or relatively rapidly become resistant to cisplatin … WebCisplatin is a chemotherapy drug. You might have it as a treatment for a number of different types of cancer. You might have cisplatin on its own or in combination with other … chinesische raumstation tiangong 2WebOct 17, 2012 · Combination cisplatin-based chemotherapy could be a viable option for patients of good performance status with recurrent/metastatic cervical cancer, but further trials that report adequate survival and QoL data are sought. Response rates and improvements in survival are low. Cisplatin-based combinat … grange offices omagh

"WebNov 8, 2024 · Cisplatin-based combination chemotherapy has obtained some progress in the clinic. For example, cisplatin combined with etoposide or irinotecan for lung cancer; cisplatin combined with 5-fluorouracil, or gemcitabine, or paclitaxel for head and neck cancer ( Gerweck, 2000; Chou, 2006; Liu et al., 2024; Yu et al., 2024 ). " - Cisplatin-based combination chemotherapy

Cisplatin-based combination chemotherapy

Multidisciplinary management in the treatment of intrahepatic ...

WebComparison of single agent versus combined chemotherapy in previously treated patients with advanced urothelial carcinoma: a meta-analysis Xiao-Jun Wu, Yi Zhi, Peng He, Xiao … WebCurrently, the standard first-line chemotherapy regimen is systemic administration of platinum-based chemotherapy combined with a taxane. A major problem besides cisplatin resistance (occurring in nearly one-third of patients) …

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WebChemotherapy consisted of cisplatin-based combination treatment and radiotherapy was given as whole-brain irradiation of 30 to 40 Gy and in single cases combined with a boost of 10 Gy to single lesions. Results: Overall, 10 patients achieved long-term survival (23%; 95% confidence interval [CI], 10.1% to 35.4%). WebFeb 16, 2024 · Common side effects of cisplatin may include: hearing problems; kidney problems; numbness or tingling; nausea, vomiting; or. bone marrow suppression. This is …

WebCisplatin and carboplatin based combinations are not used as an initial therapy. The indications for these two drugs are primary resistant malignant lymphoma and multiple myeloma, or relapses of these diseases not responding to conventional therapy. Web1 day ago · Metabolites of melatonin can also serve protective roles against DNA damage, but while combined with chemotherapeutic agents, including doxorubicin, cytarabine, daunorubicin, and etoposide, melatonin exerts a synergistic effect on inducing cytotoxicity and apoptosis in cancer cells [26]. Table 2. Chemotherapy related MMR mutations

WebIn this network meta-analysis, we found that patients who received a triple combination of platinum-based chemotherapy reported more hematological complications such as anemia and thrombocytopenia but provided relatively higher PFS and OS. In our study, all patients were sensitive to platinum-based chemotherapy during the first-line treatment. WebJul 1, 2007 · Conclusion: Cisplatin-based chemotherapy during pelvic radiation therapy improves long-term PFS and OS among locally advanced cervical cancer patients …

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WebCisplatin is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as an "alkylating agent." (For more detail, see "How Cisplatin Works" section below). What Cisplatin Is Used For: Treatment of advanced bladder cancer, metastatic ovarian cancer, and metastatic testicular cancer. grange omagh district councilWebTherapeutic efficacy of cisplatin-based treatment of late stage urothelial carcinoma (UC) is limited by chemoresistance. To elucidate underlying mechanisms and to develop new … grange of berryhillWebAmong the three paclitaxel‐based combination regimens, symptomatic radiation pneumonia was significantly increased in TC and TF on weekly regimens compared with … chinesische raumstation liveWebSep 21, 2016 · Cisplatin-based chemotherapy during pelvic radiation therapy improves long-term PFS and OS among locally advanced cervical cancer patients collectively and … grange oaks holly mi grange on farrellyWebDec 11, 2024 · Combination treatment with Tmab and nabPTX demonstrated a promising anti-tumor effect without any severe adverse effects. In the absence of definitive clinical trials, which are unlikely to be performed due to the rarity of this tumor, we believe that our case report suggests a potential utility of Tmab-based chemotherapy for HER2-positive … grange oaks apartments holly miWeb1 day ago · MMR status is an effective means to predict the response to adjuvant 5-FU-based chemotherapy in CRC patients [21]. ... (combination of irinotecan, 5-FU, and … grange officers